My work spans multiple disciplines (clinical trials, epidemiology, diagnostics, health economics, anthropology) but is unified by an unwavering drive to reduce mortality and morbidity from advanced HIV disease.
I joined the Faculty of Infectious and Tropical Diseases in 2017 and was based in Gaborone, Botswana for four years where I worked as the Lead Clinician for the AMBIsome Therapy Induction OptimisatioN (AMBITION) trial. AMBITION was a phase III randomised controlled trial of a single, high-dose liposomal amphotericin regimen for HIV-associated cryptococcal meningitis and recruited patients from six sites across five countries in Southern Africa.
I returned to the UK in 2021 and following the success of the trial I am co-investigator on a number of research and non-research grants aimed at maximising the impact of the AMBITION regimen in routine care settings and applying research advances in cryptococcal meningitis to other HIV-associated fungal infections.
Alongside research I work two-days a week for the NHS as a HIV and Sexual Health doctor.
I joined the Faculty of Infectious and Tropical Diseases in 2017 and was based in Gaborone, Botswana for four years where I worked as the Lead Clinician for the AMBIsome Therapy Induction OptimisatioN (AMBITION) trial. AMBITION was a phase III randomised controlled trial of a single, high-dose liposomal amphotericin regimen for HIV-associated cryptococcal meningitis and recruited patients from six sites across five countries in Southern Africa.
I returned to the UK in 2021 and following the success of the trial I am co-investigator on a number of research and non-research grants aimed at maximising the impact of the AMBITION regimen in routine care settings and applying research advances in cryptococcal meningitis to other HIV-associated fungal infections.
Alongside research I work two-days a week for the NHS as a HIV and Sexual Health doctor.
Affiliations
Department of Clinical Research
Faculty of Infectious and Tropical Diseases
Teaching
I am module organiser of HIV 3174 which is an intensive face-to-face module taking place in Term 3. I lead the HIV component of the Diploma in Tropical Medicine and Hygiene and am a distance learning tutor on the IDM 501 HIV/AIDS module. I supervise research projects conducted by MSc students and I am currently supervising three PhD students. I have completed Module 1 and Module 2 of the Postgraduate Certificate in Learning and Teaching and am a Fellow of the Higher Education Academy.
Research
I am involved in a number of ongoing research projects including:
IMPRINT - an NIHR Global Health Research Group for HIV-associated fungal infections
SHARE-CM - an implementation project aimed at reducing mortality from cryptococcal meningitis in routine care
EFFECT - a clinical trial of combination anti-fungal therapy for cryptococcal antigenaemia
IMPALA - a clinical trial of injectable antiretroviral therapy for individuals with a history of challenges with adherence to oral treatment
IMPRINT - an NIHR Global Health Research Group for HIV-associated fungal infections
SHARE-CM - an implementation project aimed at reducing mortality from cryptococcal meningitis in routine care
EFFECT - a clinical trial of combination anti-fungal therapy for cryptococcal antigenaemia
IMPALA - a clinical trial of injectable antiretroviral therapy for individuals with a history of challenges with adherence to oral treatment
Research Area
Clinical drug trials
Clinical trials
Diagnostics
Health economics
Medical anthropology
Anthropology
Implementation science
Disease and Health Conditions
HIV/AIDS
Sexually transmitted infections
Meningitis
Country
Botswana
Uganda
Malawi
Zimbabwe
South Africa
United Kingdom
Democratic Republic of the Congo
Mozambique
Guinea
Vietnam
Region
Sub-Saharan Africa (all income levels)
Selected Publications
Relative Contribution of Pharmacokinetics and Immune Signatures to Clinical Outcomes in Patients With HIV-associated Cryptococcal Meningitis
2025
Open Forum Infectious Diseases
Interventions to Support People With HIV Following Hospital Discharge: A Systematic Review
2025
Open forum infectious diseases
Recent Antiretroviral Therapy Initiation Is Associated With Increased Mortality Risk in Human Immunodeficiency Virus-associated Cryptococcal Meningitis: An Analysis of Clinical Trial Data From Africa.
2025
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
